Burkholderia pseudomallei K96243, BPSL2098 (ispF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2098
Name
ispF
Replicon chromosome 1
Genomic location 2518066 - 2518554 (- strand)

Cross-References

RefSeq YP_108695.1
GI 53719709
Entrez 3092071
GI 53719709
INSDC CAH36101.1
NCBI Locus Tag BPSL2098
RefSeq YP_108695.1,GeneID
UniParc UPI000043B257
UniProtKB Acc Q63T71
UniProtKB ID ISPF_BURPS
UniRef100 UniRef100_A3MKM3
UniRef50 UniRef50_Q8EBR3
UniRef90 UniRef90_A3MKM3

Product

Feature Type CDS
Coding Frame 1
Product Name
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Synonyms
Evidence for Translation
Charge (pH 7) -0.84
Kyte-Doolittle Hydrophobicity Value 0.031
Molecular Weight (kDa) 17174.4
Isoelectric Point (pI) 6.68

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3JVH LYASE 09/16/09 Crystal structure of 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase from Burkholderia pseudomallei with FOL fragment 8395 BURKHOLDERIA PSEUDOMALLEI 1.69 X-RAY DIFFRACTION 100.0
3F0F LYASE 10/24/08 Co-crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei with hydrolyzed CDP BURKHOLDERIA PSEUDOMALLEI 2.09 X-RAY DIFFRACTION 100.0
3F0E LYASE 10/24/08 Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI 2.05 X-RAY DIFFRACTION 100.0
3IKE LYASE 08/05/09 Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei with cytosine BURKHOLDERIA PSEUDOMALLEI 2.3 X-RAY DIFFRACTION 100.0
3K2X LYASE 09/30/09 Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei in complex with 5'-iodo-cytosine BURKHOLDERIA PSEUDOMALLEI 1.85 X-RAY DIFFRACTION 100.0
3F0G LYASE 10/24/08 Co-crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase with CMP BURKHOLDERIA PSEUDOMALLEI 2.08 X-RAY DIFFRACTION 100.0
3K14 LYASE 09/25/09 Co-crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei with FOL fragment 535, ethyl 3-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole-2-carboxylate BURKHOLDERIA PSEUDOMALLEI 1.7 X-RAY DIFFRACTION 100.0
3IKF LYASE 08/05/09 Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei with FOL fragment 717, imidazo[2,,1-b][1,3]thiazol-6-ylmethanol BURKHOLDERIA PSEUDOMALLEI 2.07 X-RAY DIFFRACTION 100.0
3F0D LYASE 10/24/08 High resolution crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphatase synthase from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI 1.2 X-RAY DIFFRACTION 100.0
3IEW LYASE 07/23/09 Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei with bound CTP and CDP BURKHOLDERIA PSEUDOMALLEI 2.1 X-RAY DIFFRACTION 100.0
6MWF LYASE 10/29/18 Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) Burkholderia pseudomallei in complex with ligand HGN-0459 BURKHOLDERIA PSEUDOMALLEI (STRAIN 1710B) 1.75 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 519 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001805 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2098
Search term: ispF

References

No references are associated with this feature.