Burkholderia pseudomallei K96243, BPSL2096

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2096
Name
Replicon chromosome 1
Genomic location 2516543 - 2517091 (+ strand)

Cross-References

RefSeq YP_108693.1
GI 53719707
Entrez 3093608
GI 53719707
INSDC CAH36099.1
NCBI Locus Tag BPSL2096
RefSeq YP_108693.1,GeneID
UniParc UPI000043B255
UniProtKB Acc Q63T73
UniProtKB ID Q63T73_BURPS
UniRef100 UniRef100_A0A095G989
UniRef50 UniRef50_A9II51
UniRef90 UniRef90_A0A069PQY9

Product

Feature Type CDS
Coding Frame 1
Product Name
hydroperoxide reductase
Synonyms
Evidence for Translation
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (18.3 kDa, pI 4.76, PMID:21960737)
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (13.3 kDa, pI 4.70, PMID:21960737)
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (18.1 kDa, pI 4.94, PMID:21960737)
Detected in B. pseudomallei strain DD503 using trypsin shaving and mass spectrometry (PMID:21391724). Found in at least two preparations.
Charge (pH 7) -7.13
Kyte-Doolittle Hydrophobicity Value -0.308
Molecular Weight (kDa) 20304.8
Isoelectric Point (pI) 4.81

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization
Detected in Triton-insoluble fraction of lysozyme-treated B. pseudomallei DD503 cells using trypsin shaving and mass spectrometry (PMID:21391724).

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 570 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001803 (652 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2096

Human Homologs

Ensembl 97, assembly GRCh38.p12
peroxiredoxin 3 [Source:HGNC Symbol;Acc:HGNC:9354]
E-value: 1.6e-25
Percent Identity: 39.7

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268