Burkholderia pseudomallei K96243, BPSL1955 (scoA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL1955
Name
scoA
Replicon chromosome 1
Genomic location 2326613 - 2327317 (- strand)

Cross-References

RefSeq YP_108553.1
GI 53719567
Entrez 3093698
GI 53719567
INSDC CAH35954.1
NCBI Locus Tag BPSL1955
RefSeq YP_108553.1,GeneID
UniParc UPI000043B1CA
UniProtKB Acc Q63TL3
UniProtKB ID Q63TL3_BURPS
UniRef100 UniRef100_A0A095MAA7
UniRef50 UniRef50_P56006
UniRef90 UniRef90_A0A069B4K8

Product

Feature Type CDS
Coding Frame 1
Product Name
succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A
Synonyms
Evidence for Translation
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (24.6 kDa, pI 5.34, PMID:21960737)
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (25.2 kDa, pI 5.89, PMID:21960737)
Charge (pH 7) -3.37
Kyte-Doolittle Hydrophobicity Value -0.107
Molecular Weight (kDa) 25217.6
Isoelectric Point (pI) 5.42

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 282 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001297 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL1955
Search term: scoA

Human Homologs

Ensembl 97, assembly GRCh38.p12
3-oxoacid CoA-transferase 1 [Source:HGNC Symbol;Acc:HGNC:8527]
E-value: 4.5e-76
Percent Identity: 57.0

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268