Burkholderia pseudomallei K96243, BPSL1945 (thrS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL1945
Name
thrS
Replicon chromosome 1
Genomic location 2314737 - 2316644 (- strand)

Cross-References

RefSeq YP_108544.1
GI 53719558
Entrez 3092747
GI 53719558
INSDC CAH35944.1
NCBI Locus Tag BPSL1945
RefSeq YP_108544.1,GeneID
UniParc UPI000043B1C1
UniProtKB Acc Q63TM2
UniProtKB ID SYT_BURPS
UniRef100 UniRef100_A3MJT8
UniRef50 UniRef50_Q83C10
UniRef90 UniRef90_Q2SVD8

Product

Feature Type CDS
Coding Frame 1
Product Name
threonyl-tRNA synthetase
Synonyms
Evidence for Translation
Charge (pH 7) -8.36
Kyte-Doolittle Hydrophobicity Value -0.451
Molecular Weight (kDa) 72264.6
Isoelectric Point (pI) 6.38

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001306 (656 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL1945
Search term: thrS

Human Homologs

Ensembl 97, assembly GRCh38.p12
threonyl-tRNA synthetase like 2 [Source:HGNC Symbol;Acc:HGNC:24728]
E-value: 3.1e-132
Percent Identity: 39.7

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268