Burkholderia pseudomallei K96243, BPSL1874

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL1874
Name
Replicon chromosome 1
Genomic location 2227421 - 2229955 (- strand)

Cross-References

RefSeq YP_108473.1
GI 53719487
Entrez 3091947
GI 53719487
NCBI Locus Tag BPSL1874
RefSeq YP_108473.1,GeneID
UniProtKB Acc Q63TU3
UniProtKB ID Q63TU3_BURPS

Product

Feature Type CDS
Coding Frame 1
Product Name
ribonuclease
Synonyms
Evidence for Translation
Charge (pH 7) 24.04
Kyte-Doolittle Hydrophobicity Value -0.424
Molecular Weight (kDa) 93866.3
Isoelectric Point (pI) 9.55

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 541 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001373 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL1874
Search term: ribonuclease

Human Homologs

Ensembl 97, assembly GRCh38.p12
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [Source:HGNC Symbol;Acc:HGNC:20604]
E-value: 6.1e-51
Percent Identity: 28.7
Ensembl 97, assembly GRCh38.p12
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [Source:HGNC Symbol;Acc:HGNC:20604]
E-value: 6.1e-51
Percent Identity: 28.7
Ensembl 97, assembly GRCh38.p12
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [Source:HGNC Symbol;Acc:HGNC:20604]
E-value: 6.1e-51
Percent Identity: 28.7

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268