Burkholderia pseudomallei K96243, BPSL1554 (mntH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL1554
Name
mntH
Replicon chromosome 1
Genomic location 1802768 - 1804075 (- strand)

Cross-References

RefSeq YP_108174.1
GI 53719188
Entrez 3092464
GI 53719188
INSDC CAH35555.1
NCBI Locus Tag BPSL1554
RefSeq YP_108174.1,GeneID
UniParc UPI000043B053
UniProtKB Acc Q63UP2
UniProtKB ID Q63UP2_BURPS
UniRef100 UniRef100_A0A069B1S4
UniRef50 UniRef50_Q13Y23
UniRef90 UniRef90_Q2SWA3

Product

Feature Type CDS
Coding Frame 1
Product Name
MntH
Product Name Confidence: Class 2
Synonyms metal-ion transport system, membrane protein
Evidence for Translation
Charge (pH 7) 13.24
Kyte-Doolittle Hydrophobicity Value 0.783
Molecular Weight (kDa) 45107.8
Isoelectric Point (pI) 10.83

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 297 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004834 (656 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL1554
Search term: mntH
Search term: MntH

Human Homologs

Ensembl 97, assembly GRCh38.p12
solute carrier family 11 member 2 [Source:HGNC Symbol;Acc:HGNC:10908]
E-value: 1.0e-49
Percent Identity: 35.7
Ensembl 97, assembly GRCh38.p12
solute carrier family 11 member 2 [Source:HGNC Symbol;Acc:HGNC:10908]
E-value: 1.0e-49
Percent Identity: 35.7
Ensembl 97, assembly GRCh38.p12
solute carrier family 11 member 2 [Source:HGNC Symbol;Acc:HGNC:10908]
E-value: 1.0e-49
Percent Identity: 35.7
Ensembl 97, assembly GRCh38.p12
solute carrier family 11 member 2 [Source:HGNC Symbol;Acc:HGNC:10908]
E-value: 1.0e-49
Percent Identity: 35.7
Ensembl 97, assembly GRCh38.p12
solute carrier family 11 member 2 [Source:HGNC Symbol;Acc:HGNC:10908]
E-value: 1.0e-49
Percent Identity: 35.7
Ensembl 97, assembly GRCh38.p12
solute carrier family 11 member 2 [Source:HGNC Symbol;Acc:HGNC:10908]
E-value: 1.0e-49
Percent Identity: 35.7
Ensembl 97, assembly GRCh38.p12
solute carrier family 11 member 2 [Source:HGNC Symbol;Acc:HGNC:10908]
E-value: 1.0e-49
Percent Identity: 35.7
Ensembl 97, assembly GRCh38.p12
solute carrier family 11 member 2 [Source:HGNC Symbol;Acc:HGNC:10908]
E-value: 1.0e-49
Percent Identity: 35.7

References

In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS
Microbiology 2007 Aug;153(Pt 8):2689-2699
PubMed ID: 17660433
Mn2+ and bacterial pathogenesis.
Zaharik ML, Finlay BB
Front Biosci 2004 May 1;9:1035-42
PubMed ID: 14977526
The NRAMP proteins of Salmonella typhimurium and Escherichia coli are selective manganese transporters involved in the response to reactive oxygen.
Kehres DG, Zaharik ML, Finlay BB, Maguire ME
Mol Microbiol 2000 Jun;36(5):1085-100
PubMed ID: 10844693