Burkholderia pseudomallei K96243, BPSL1404 (clpX)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL1404
Name
clpX
Replicon chromosome 1
Genomic location 1632520 - 1633812 (+ strand)

Cross-References

RefSeq YP_108026.1
GI 53719040
Entrez 3093205
GI 53719040
INSDC CAH35405.1
NCBI Locus Tag BPSL1404
RefSeq YP_108026.1,GeneID
UniParc UPI00004E1860
UniProtKB Acc Q63V40
UniProtKB ID CLPX_BURPS
UniRef100 UniRef100_A3NWA5
UniRef50 UniRef50_Q8UFY5
UniRef90 UniRef90_Q1BH84

Product

Feature Type CDS
Coding Frame 1
Product Name
ATP-dependent protease ATP-binding subunit ClpX
Synonyms
Evidence for Translation
Charge (pH 7) -5.23
Kyte-Doolittle Hydrophobicity Value -0.171
Molecular Weight (kDa) 47086.8
Isoelectric Point (pI) 5.44

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 621 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001786 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL1404
Search term: clpX

Human Homologs

Ensembl 97, assembly GRCh38.p12
caseinolytic mitochondrial matrix peptidase chaperone subunit [Source:HGNC Symbol;Acc:HGNC:2088]
E-value: 1.9e-88
Percent Identity: 44.7

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268