Burkholderia pseudomallei K96243, BPSL1349 (carA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL1349
Name
carA
Replicon chromosome 1
Genomic location 1575304 - 1576449 (+ strand)

Cross-References

RefSeq YP_107974.1
GI 53718988
Entrez 3092517
GI 53718988
INSDC CAH35347.1
NCBI Locus Tag BPSL1349
RefSeq YP_107974.1,GeneID
UniParc UPI000043AF8C
UniProtKB Acc Q63V92
UniProtKB ID Q63V92_BURPS
UniRef100 UniRef100_A1V313
UniRef50 UniRef50_P0A6F2
UniRef90 UniRef90_Q2SUV4

Product

Feature Type CDS
Coding Frame 1
Product Name
carbamoyl phosphate synthase small subunit
Synonyms
Evidence for Translation
Charge (pH 7) -0.27
Kyte-Doolittle Hydrophobicity Value -0.015
Molecular Weight (kDa) 40652.9
Isoelectric Point (pI) 6.95

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 627 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001127 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL1349
Search term: carA

Human Homologs

Ensembl 97, assembly GRCh38.p12
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase [Source:HGNC Symbol;Acc:HGNC:1424]
E-value: 4.9e-64
Percent Identity: 38.2
Ensembl 97, assembly GRCh38.p12
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase [Source:HGNC Symbol;Acc:HGNC:1424]
E-value: 4.9e-64
Percent Identity: 38.2

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268