Burkholderia pseudomallei K96243, BPSL1164 (purD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL1164
Name
purD
Replicon chromosome 1
Genomic location 1342594 - 1343871 (- strand)

Cross-References

RefSeq YP_107786.1
GI 53718800
Entrez 3094818
GI 53718800
INSDC CAH35159.1
NCBI Locus Tag BPSL1164
RefSeq YP_107786.1,GeneID
UniParc UPI000043AED0
UniProtKB Acc Q63VT0
UniProtKB ID Q63VT0_BURPS
UniRef100 UniRef100_A3NT47
UniRef50 UniRef50_A1V2G1
UniRef90 UniRef90_A1V2G1

Product

Feature Type CDS
Coding Frame 1
Product Name
phosphoribosylamine--glycine ligase
Synonyms
Evidence for Translation
Charge (pH 7) -3.40
Kyte-Doolittle Hydrophobicity Value -0.125
Molecular Weight (kDa) 45418.4
Isoelectric Point (pI) 6.45

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 626 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002180 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL1164
Search term: purD

Human Homologs

Ensembl 97, assembly GRCh38.p12
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [Source:HGNC Symbol;Acc:HGNC:4163]
E-value: 8.0e-108
Percent Identity: 49.5
Ensembl 97, assembly GRCh38.p12
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [Source:HGNC Symbol;Acc:HGNC:4163]
E-value: 8.0e-108
Percent Identity: 49.5
Ensembl 97, assembly GRCh38.p12
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [Source:HGNC Symbol;Acc:HGNC:4163]
E-value: 8.0e-108
Percent Identity: 49.5
Ensembl 97, assembly GRCh38.p12
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [Source:HGNC Symbol;Acc:HGNC:4163]
E-value: 8.0e-108
Percent Identity: 49.5

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268