Burkholderia pseudomallei K96243, BPSL0896 (icd)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL0896
Name
icd
Replicon chromosome 1
Genomic location 1044191 - 1045450 (+ strand)

Cross-References

RefSeq YP_107522.1
GI 53718536
Entrez 3092199
GI 53718536
INSDC CAH34889.1
NCBI Locus Tag BPSL0896
RefSeq YP_107522.1,GeneID
UniParc UPI000043ADCB
UniProtKB Acc Q63WJ4
UniProtKB ID Q63WJ4_BURPS
UniRef100 UniRef100_A0A069B574
UniRef50 UniRef50_Q59940
UniRef90 UniRef90_A3N6N5

Product

Feature Type CDS
Coding Frame 1
Product Name
isocitrate dehydrogenase
Synonyms
Evidence for Translation
Charge (pH 7) -4.84
Kyte-Doolittle Hydrophobicity Value -0.190
Molecular Weight (kDa) 46145.8
Isoelectric Point (pI) 5.58

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown (This protein may have multiple localization sites) Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3DMS OXIDOREDUCTASE 07/01/08 1.65A crystal structure of isocitrate dehydrogenase from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI 1.65 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 605 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002390 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL0896
Search term: icd

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268