Burkholderia pseudomallei K96243, BPSL0869 (argF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL0869
Name
argF
Replicon chromosome 1
Genomic location 1009176 - 1010105 (- strand)

Cross-References

RefSeq YP_107494.1
GI 53718508
Entrez 3092982
GI 53718508
INSDC CAH34861.1
NCBI Locus Tag BPSL0869
RefSeq YP_107494.1,GeneID
UniParc UPI000043ADAF
UniProtKB Acc Q63WM2
UniProtKB ID OTC_BURPS
UniRef100 UniRef100_Q62M76
UniRef50 UniRef50_Q02047
UniRef90 UniRef90_Q1BU60

Product

Feature Type CDS
Coding Frame 1
Product Name
ornithine carbamoyltransferase
Synonyms
Evidence for Translation
Charge (pH 7) -9.23
Kyte-Doolittle Hydrophobicity Value -0.310
Molecular Weight (kDa) 35417.9
Isoelectric Point (pI) 5.56

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4F2G TRANSFERASE 05/07/12 The Crystal Structure of Ornithine carbamoyltransferase from Burkholderia thailandensis E264 BURKHOLDERIA THAILANDENSIS 2.1 X-RAY DIFFRACTION 98.1

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 649 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002416 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL0869
Search term: argF

Human Homologs

Ensembl 97, assembly GRCh38.p12
ornithine carbamoyltransferase [Source:HGNC Symbol;Acc:HGNC:8512]
E-value: 1.0e-56
Percent Identity: 40.5

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268