Burkholderia pseudomallei K96243, BPSL0820 (flhA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL0820
Name
flhA
Replicon chromosome 1
Genomic location 954204 - 955310 (+ strand)

Cross-References

RefSeq YP_107444.1
GI 53718458
Entrez 3091474
GI 53718458
INSDC CAH34811.1
NCBI Locus Tag BPSL0820
RefSeq YP_107444.1,GeneID
UniParc UPI000043AD7D
UniProtKB Acc Q63WS2
UniProtKB ID Q63WS2_BURPS
UniRef100 UniRef100_Q63WS2
UniRef50 UniRef50_P46415
UniRef90 UniRef90_Q13UL8

Product

Feature Type CDS
Coding Frame 1
Product Name
glutathione-dependent formaldehyde dehydrogenase
Synonyms
Evidence for Translation
Charge (pH 7) -2.37
Kyte-Doolittle Hydrophobicity Value 0.046
Molecular Weight (kDa) 39580.4
Isoelectric Point (pI) 6.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 554 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG005368 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL0820
Search term: flhA

Human Homologs

Ensembl 97, assembly GRCh38.p12
alcohol dehydrogenase 5 (class III), chi polypeptide [Source:HGNC Symbol;Acc:HGNC:253]
E-value: 1.1e-134
Percent Identity: 61.3

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268