Burkholderia pseudomallei K96243, BPSL0443 (gpmA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL0443
Name
gpmA
Replicon chromosome 1
Genomic location 483930 - 484679 (- strand)

Cross-References

RefSeq YP_107068.1
GI 53718082
Entrez 3093540
GI 53718082
INSDC CAH34431.1
NCBI Locus Tag BPSL0443
RefSeq YP_107068.1,GeneID
UniParc UPI000043AC08
UniProtKB Acc Q63XU7
UniProtKB ID GPMA_BURPS
UniRef100 UniRef100_A3MQ23
UniRef50 UniRef50_Q39CN6
UniRef90 UniRef90_Q39CN6

Product

Feature Type CDS
Coding Frame 1
Product Name
phosphoglyceromutase
Synonyms
Evidence for Translation
Charge (pH 7) -0.59
Kyte-Doolittle Hydrophobicity Value -0.373
Molecular Weight (kDa) 27892.5
Isoelectric Point (pI) 6.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3GW8 ISOMERASE 03/31/09 Crystal structure of phosphoglyceromutase from Burkholderia pseudomallei with vanadate and glycerol BURKHOLDERIA PSEUDOMALLEI 1.93 X-RAY DIFFRACTION 100.0
3LNT ISOMERASE 02/03/10 Crystal structure of phosphoglyceromutase from Burkholderia Pseudomallei 1710B with bound malonic acid BURKHOLDERIA PSEUDOMALLEI 2.1 X-RAY DIFFRACTION 100.0
3FDZ ISOMERASE 11/26/08 Crystal structure of phosphoglyceromutase from burkholderia pseudomallei 1710b with bound 2,3-diphosphoglyceric acid and 3-phosphoglyceric acid BURKHOLDERIA PSEUDOMALLEI 1710B 2.25 X-RAY DIFFRACTION 100.0
3EZN ISOMERASE 10/23/08 Crystal structure of phosphoglyceromutase from burkholderia pseudomallei 1710b BURKHOLDERIA PSEUDOMALLEI 1710B 2.1 X-RAY DIFFRACTION 100.0
3GP5 ISOMERASE 03/20/09 Crystal structure of phosphoglyceromutase from Burkholderia pseudomallei with 3-phosphoglyceric acid and vanadate BURKHOLDERIA PSEUDOMALLEI 2.25 X-RAY DIFFRACTION 100.0
3GP3 ISOMERASE 03/20/09 Crystal structure of phosphoglyceromutase from Burkholderia pseudomallei with 2-phosphoserine BURKHOLDERIA PSEUDOMALLEI 1.5 X-RAY DIFFRACTION 100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
Pentaglyme DB02580 DrugBank 5.1.5 Q3JWH7 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 100.0 249 1.1e-141

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 431 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002703 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL0443
Search term: gpmA

Human Homologs

Ensembl 97, assembly GRCh38.p12
phosphoglycerate mutase 1 [Source:HGNC Symbol;Acc:HGNC:8888]
E-value: 3.9e-86
Percent Identity: 60.3

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268