Burkholderia pseudomallei K96243, BPSL0212 (metK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL0212
Name
metK
Replicon chromosome 1
Genomic location 220451 - 221638 (+ strand)

Cross-References

RefSeq YP_106840.1
GI 53717854
Entrez 3091760
GI 53717854
INSDC CAH34199.1
NCBI Locus Tag BPSL0212
RefSeq YP_106840.1,GeneID
UniParc UPI000043AB27
UniProtKB Acc Q63YH5
UniProtKB ID METK_BURPS
UniRef100 UniRef100_A3MRQ4
UniRef50 UniRef50_P13444
UniRef90 UniRef90_Q146W0

Product

Feature Type CDS
Coding Frame 1
Product Name
S-adenosylmethionine synthetase
Synonyms
Evidence for Translation
Charge (pH 7) -11.95
Kyte-Doolittle Hydrophobicity Value -0.165
Molecular Weight (kDa) 42640.8
Isoelectric Point (pI) 4.96

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3IML TRANSFERASE 08/10/09 Crystal Structure Of S-Adenosylmethionine Synthetase From Burkholderia Pseudomallei BURKHOLDERIA PSEUDOMALLEI 2.35 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 582 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002906 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL0212
Search term: metK

Human Homologs

Ensembl 97, assembly GRCh38.p12
methionine adenosyltransferase 1A [Source:HGNC Symbol;Acc:HGNC:6903]
E-value: 1.2e-113
Percent Identity: 55.8

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268