Burkholderia cenocepacia H111, I35_RS21090 (bceM)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Burkholderia cenocepacia H111
Locus Tag
NCBI Old Locus TagI35_2574%2CI35_4922
Replicon chromosome 2
Genomic location 1022456 - 1023421 (- strand)
CommentMember of the bce-II gene cluster


RefSeq WP_006495943.1
GI 493542076
NCBI Locus Tag I35_RS21090
NCBI Old Locus Tag I35_2574%2CI35_4922
RefSeq WP_006495943.1


Feature Type CDS
Coding Frame 1
Product Name
GDP-6-deoxy-D-lyxo-4-hexulose reductase BceM
Synonyms GDP-6-deoxy-D-lyxo-4-hexulose reductase
Evidence for Translation
Charge (pH 7) 2.14
Kyte-Doolittle Hydrophobicity Value -0.026
Molecular Weight (kDa) 34446.8
Isoelectric Point (pI) 8.19

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4LW8 ISOMERASE 07/26/13 Crystal structure of a putative epimerase from Burkholderia cenocepacia J2315 BURKHOLDERIA CENOCEPACIA 2.1 X-RAY DIFFRACTION 99.7

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000738 (646 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: I35_RS21090
Search term: bceM

Human Homologs


Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.
Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM
Appl Environ Microbiol 2010 Jan;76(2):441-50
PubMed ID: 19948863