Burkholderia cenocepacia H111, I35_RS18935 (rpfR)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Burkholderia cenocepacia H111
Locus Tag
NCBI Old Locus TagI35_2280%2CI35_4474
Replicon chromosome 2
Genomic location 544979 - 546982 (+ strand)


RefSeq WP_006495698.1
GI 493541828
NCBI Locus Tag I35_RS18935
NCBI Old Locus Tag I35_2280%2CI35_4474
RefSeq WP_006495698.1


Feature Type CDS
Coding Frame 1
Product Name
cis-2-dodecenoic acid receptor RpfR
Product Name Confidence: Class 1
Synonyms RNase II stability modulator
Evidence for Translation
Charge (pH 7) -17.81
Kyte-Doolittle Hydrophobicity Value -0.033
Molecular Weight (kDa) 73376.6
Isoelectric Point (pI) 5.23

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004646 (511 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: I35_RS18935
Search term: rpfR


Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover.
Deng Y, Schmid N, Wang C, Wang J, Pessi G, Wu D, Lee J, Aguilar C, Ahrens CH, Chang C, Song H, Eberl L, Zhang LH
Proc Natl Acad Sci U S A 2012 Sep 18;109(38):15479-84
PubMed ID: 22949660
Mutation of the cyclic di-GMP phosphodiesterase gene in Burkholderia lata SK875 attenuates virulence and enhances biofilm formation.
Jung HI, Kim YJ, Lee YJ, Lee HS, Lee JK, Kim SK
J Microbiol 2017 Oct;55(10):800-808
PubMed ID: 28956352
High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111.
Schmid N, Suppiger A, Steiner E, Pessi G, Kaever V, Fazli M, Tolker-Nielsen T, Jenal U, Eberl L
Microbiology 2017 May;163(5):754-764
PubMed ID: 28463102
Cis-2-dodecenoic acid quorum sensing system modulates N-acyl homoserine lactone production through RpfR and cyclic di-GMP turnover in Burkholderia cenocepacia.
Deng Y, Lim A, Wang J, Zhou T, Chen S, Lee J, Dong YH, Zhang LH
BMC Microbiol 2013 Jul 1;13:148
PubMed ID: 23815566