Burkholderia cenocepacia H111, I35_RS01705 (tssK)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Burkholderia cenocepacia H111
Locus Tag
NCBI Old Locus TagI35_0329%2CI35_0388
Synonym: bcsO
Replicon chromosome 1
Genomic location 348769 - 350115 (- strand)
CommentPart of the T6SS gene cluster


RefSeq WP_006477098.1
GI 493523019
NCBI Locus Tag I35_RS01705
NCBI Old Locus Tag I35_0329%2CI35_0388
RefSeq WP_006477098.1


Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssK
Product Name Confidence: Class 1
Synonyms type VI secretion protein
Evidence for Translation
Charge (pH 7) -10.92
Kyte-Doolittle Hydrophobicity Value -0.040
Molecular Weight (kDa) 49904.3
Isoelectric Point (pI) 5.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000363 (632 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: I35_RS01705
Search term: tssK


A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia.
Aubert DF, Flannagan RS, Valvano MA
Infect Immun 2008 May;76(5):1979-91
PubMed ID: 18316384
TssK is a trimeric cytoplasmic protein interacting with components of both phage-like and membrane anchoring complexes of the type VI secretion system.
Zoued A, Durand E, Bebeacua C, Brunet YR, Douzi B, Cambillau C, Cascales E, Journet L
J Biol Chem 2013 Sep 20;288(38):27031-41
PubMed ID: 23921384
Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia.
Aubert DF, Hu S, Valvano MA
Microbiology 2015 Nov;161(11):2161-73
PubMed ID: 26364149