Burkholderia lata 383, BCEP18194_RS34100 (bceD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia lata 383
GCF_000012945.1|latest
Locus Tag
BCEP18194_RS34100
NCBI Old Locus TagBcep18194_B2274
Name
bceD
Replicon chromosome 2
Genomic location 2597624 - 2598067 (- strand)
CommentMember of the bce-I gene cluster

Cross-References

RefSeq WP_011355867.1
GI 499675133
NCBI Locus Tag BCEP18194_RS34100
NCBI Old Locus Tag Bcep18194_B2274
RefSeq WP_011355867.1

Product

Feature Type CDS
Coding Frame NA
Product Name
phosphotyrosine phosphatase BceD
Product Name Confidence: Class 2
Synonyms exopolysaccharide biosynthesis protein
Evidence for Translation
Charge (pH 7) 3.58
Kyte-Doolittle Hydrophobicity Value -0.356
Molecular Weight (kDa) 16361.5
Isoelectric Point (pI) 8.52

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004849 (632 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCEP18194_RS34100
Search term: bceD

Human Homologs

References

Functional analysis of Burkholderia cepacia genes bceD and bceF, encoding a phosphotyrosine phosphatase and a tyrosine autokinase, respectively: role in exopolysaccharide biosynthesis and biofilm formation.
Ferreira AS, Leitão JH, Sousa SA, Cosme AM, Sá-Correia I, Moreira LM
Appl Environ Microbiol 2007 Jan;73(2):524-34
PubMed ID: 17114319
Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.
Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM
Appl Environ Microbiol 2010 Jan;76(2):441-50
PubMed ID: 19948863
Tyrosine Phosphorylation and Dephosphorylation in Burkholderia cenocepacia Affect Biofilm Formation, Growth under Nutritional Deprivation, and Pathogenicity.
Andrade A, Tavares-Carreón F, Khodai-Kalaki M, Valvano MA
Appl Environ Microbiol 2016 Feb 1;82(3):843-56
PubMed ID: 26590274
The tyrosine kinase BceF and the phosphotyrosine phosphatase BceD of Burkholderia contaminans are required for efficient invasion and epithelial disruption of a cystic fibrosis lung epithelial cell line.
Ferreira AS, Silva IN, Fernandes F, Pilkington R, Callaghan M, McClean S, Moreira LM
Infect Immun 2015 Feb;83(2):812-21
PubMed ID: 25486990