Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS08350 (bceN)

Cytoplasmic Membrane
Outer Membrane

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
Locus Tag
NCBI Old Locus TagBURCENK562V_C3031
Replicon ctg7180000002940B
Genomic location 535345 - 536391 (- strand)
CommentMember of the bce-II gene cluster


RefSeq WP_006491261.1
GI 493537335
EC Number
GI 493537335
NCBI Locus Tag BURCENK562V_RS08350
NCBI Old Locus Tag BURCENK562V_C3031
RefSeq WP_006491261.1


Feature Type CDS
Coding Frame 1
Product Name
GDP-D-mannose 4,6-dehydratase BceN
Product Name Confidence: Class 2
Synonyms GDP-D-mannose dehydratase
Evidence for Translation
Charge (pH 7) -0.61
Kyte-Doolittle Hydrophobicity Value -0.341
Molecular Weight (kDa) 38958.9
Isoelectric Point (pI) 6.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003102 (653 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: bceN

Human Homologs

Ensembl 97, assembly GRCh38.p12
GDP-mannose 4,6-dehydratase [Source:HGNC Symbol;Acc:HGNC:4369]
E-value: 9.5e-99
Percent Identity: 53.0


Biochemical and functional studies on the Burkholderia cepacia complex bceN gene, encoding a GDP-D-mannose 4,6-dehydratase.
Sousa SA, Feliciano JR, Pinheiro PF, Leitão JH
PLoS One 2013;8(2):e56902
PubMed ID: 23460819
Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.
Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM
Appl Environ Microbiol 2010 Jan;76(2):441-50
PubMed ID: 19948863