Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS07625 (bceF)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Burkholderia cenocepacia K56-2Valvano
GCF_000333155.2|latest |
| Locus Tag |
BURCENK562V_RS07625
|
| NCBI Old Locus Tag | BURCENK562V_C2870 |
| Name |
bceF
|
| Replicon | ctg7180000002940B |
| Genomic location | 370203 - 372428 (+ strand) |
| Comment | Member of the bce-I gene cluster |
Cross-References
| RefSeq | WP_006482932.1 |
| GI | 493528915 |
| GI | 493528915 |
| NCBI Locus Tag | BURCENK562V_RS07625 |
| NCBI Old Locus Tag | BURCENK562V_C2870 |
| RefSeq | WP_006482932.1 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
tyrosine kinase BceF
|
| Synonyms |
exopolysaccharide biosynthesis protein |
| Evidence for Translation | |
| Charge (pH 7) | 1.93 |
| Kyte-Doolittle Hydrophobicity Value | -0.034 |
| Molecular Weight (kDa) | 79575.6 |
| Isoelectric Point (pI) | 7.78 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Orthologs/Comparative Genomics
| Burkholderia Ortholog Group |
BG004851 (638 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: BURCENK562V_RS07625
Search term: bceF
Search term: tyrosine kinase BceF
|
Human Homologs
References
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Functional analysis of Burkholderia cepacia genes bceD and bceF, encoding a phosphotyrosine phosphatase and a tyrosine autokinase, respectively: role in exopolysaccharide biosynthesis and biofilm formation.
Ferreira AS, Leitão JH, Sousa SA, Cosme AM, Sá-Correia I, Moreira LM
Appl Environ Microbiol 2007 Jan;73(2):524-34
PubMed ID: 17114319
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Comparative transcriptomic analysis of the Burkholderia cepacia tyrosine kinase bceF mutant reveals a role in tolerance to stress, biofilm formation, and virulence.
Ferreira AS, Silva IN, Oliveira VH, Becker JD, Givskov M, Ryan RP, Fernandes F, Moreira LM
Appl Environ Microbiol 2013 May;79(9):3009-20
PubMed ID: 23435894
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The tyrosine kinase BceF and the phosphotyrosine phosphatase BceD of Burkholderia contaminans are required for efficient invasion and epithelial disruption of a cystic fibrosis lung epithelial cell line.
Ferreira AS, Silva IN, Fernandes F, Pilkington R, Callaghan M, McClean S, Moreira LM
Infect Immun 2015 Feb;83(2):812-21
PubMed ID: 25486990
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Tyrosine Phosphorylation and Dephosphorylation in Burkholderia cenocepacia Affect Biofilm Formation, Growth under Nutritional Deprivation, and Pathogenicity.
Andrade A, Tavares-Carreón F, Khodai-Kalaki M, Valvano MA
Appl Environ Microbiol 2016 Feb 1;82(3):843-56
PubMed ID: 26590274
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Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.
Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM
Appl Environ Microbiol 2010 Jan;76(2):441-50
PubMed ID: 19948863
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