Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS07610 (bceC)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Burkholderia cenocepacia K56-2Valvano
GCF_000333155.2|latest |
| Locus Tag |
BURCENK562V_RS07610
|
| NCBI Old Locus Tag | BURCENK562V_C2867 |
| Name |
bceC
|
| Replicon | ctg7180000002940B |
| Genomic location | 367093 - 368505 (+ strand) |
| Comment | Member of the bce-I gene cluster |
Cross-References
| RefSeq | WP_006497289.1 |
| GI | 493543430 |
| EC Number | 1.1.1.22 |
| GI | 493543430 |
| NCBI Locus Tag | BURCENK562V_RS07610 |
| NCBI Old Locus Tag | BURCENK562V_C2867 |
| RefSeq | WP_006497289.1 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
UDP-Glucose Dehydrogenase BceC
|
| Synonyms |
UDP-glucose 6-dehydrogenase |
| Evidence for Translation | |
| Charge (pH 7) | -9.20 |
| Kyte-Doolittle Hydrophobicity Value | -0.162 |
| Molecular Weight (kDa) | 51228.5 |
| Isoelectric Point (pI) | 5.27 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 2Y0E | OXIDOREDUCTASE | 12/02/10 | BceC and the final step of UGDs reaction | BURKHOLDERIA CEPACIA | 1.75 | X-RAY DIFFRACTION | 97.9 |
| 2Y0D | OXIDOREDUCTASE | 12/02/10 | BceC mutation Y10K | BURKHOLDERIA CEPACIA | 2.8 | X-RAY DIFFRACTION | 97.7 |
| 2Y0C | OXIDOREDUCTASE | 12/02/10 | BceC mutation Y10S | BURKHOLDERIA CEPACIA | 1.75 | X-RAY DIFFRACTION | 97.7 |
Orthologs/Comparative Genomics
| Burkholderia Ortholog Group |
BG000893 (1284 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: BURCENK562V_RS07610
Search term: bceC
Search term: UDP-Glucose Dehydrogenase BceC
|
Human Homologs
|
Ensembl
97, assembly
GRCh38.p12
|
UDP-glucose 6-dehydrogenase [Source:HGNC Symbol;Acc:HGNC:12525]
E-value:
9.3e-65
Percent Identity:
35.9
|
|
Ensembl
97, assembly
GRCh38.p12
|
UDP-glucose 6-dehydrogenase [Source:HGNC Symbol;Acc:HGNC:12525]
E-value:
9.3e-65
Percent Identity:
35.9
|
References
|
Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.
Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM
Appl Environ Microbiol 2010 Jan;76(2):441-50
PubMed ID: 19948863
|
|
Structure of Burkholderia cepacia UDP-glucose dehydrogenase (UGD) BceC and role of Tyr10 in final hydrolysis of UGD thioester intermediate.
Rocha J, Popescu AO, Borges P, Mil-Homens D, Moreira LM, Sá-Correia I, Fialho AM, Frazão C
J Bacteriol 2011 Aug;193(15):3978-87
PubMed ID: 21602353
|
|
Cloning, expression, purification, crystallization and preliminary crystallographic studies of BceC, a UDP-glucose dehydrogenase from Burkholderia cepacia IST408.
Rocha J, Popescu AO, Sá-Correia I, Fialho AM, Frazão C
Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 Mar 1;66(Pt 3):269-71
PubMed ID: 20208157
|