Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS06240 (rpfR)

Cytoplasmic Membrane
Outer Membrane

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
Locus Tag
NCBI Old Locus TagBURCENK562V_C2564
Replicon ctg7180000002940B
Genomic location 67066 - 69069 (+ strand)


RefSeq WP_006488779.1
GI 493534813
GI 493534813
NCBI Locus Tag BURCENK562V_RS06240
NCBI Old Locus Tag BURCENK562V_C2564
RefSeq WP_006488779.1


Feature Type CDS
Coding Frame 1
Product Name
cis-2-dodecenoic acid receptor RpfR
Product Name Confidence: Class 2
Synonyms RNase II stability modulator
Evidence for Translation
Charge (pH 7) -17.81
Kyte-Doolittle Hydrophobicity Value -0.034
Molecular Weight (kDa) 73390.7
Isoelectric Point (pI) 5.23

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004646 (511 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: rpfR


Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover.
Deng Y, Schmid N, Wang C, Wang J, Pessi G, Wu D, Lee J, Aguilar C, Ahrens CH, Chang C, Song H, Eberl L, Zhang LH
Proc Natl Acad Sci U S A 2012 Sep 18;109(38):15479-84
PubMed ID: 22949660
Mutation of the cyclic di-GMP phosphodiesterase gene in Burkholderia lata SK875 attenuates virulence and enhances biofilm formation.
Jung HI, Kim YJ, Lee YJ, Lee HS, Lee JK, Kim SK
J Microbiol 2017 Oct;55(10):800-808
PubMed ID: 28956352
High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111.
Schmid N, Suppiger A, Steiner E, Pessi G, Kaever V, Fazli M, Tolker-Nielsen T, Jenal U, Eberl L
Microbiology 2017 May;163(5):754-764
PubMed ID: 28463102
Cis-2-dodecenoic acid quorum sensing system modulates N-acyl homoserine lactone production through RpfR and cyclic di-GMP turnover in Burkholderia cenocepacia.
Deng Y, Lim A, Wang J, Zhou T, Chen S, Lee J, Dong YH, Zhang LH
BMC Microbiol 2013 Jul 1;13:148
PubMed ID: 23815566