Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS22185 (arnA2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
GCF_000333155.2|latest
Locus Tag
BURCENK562V_RS22185
NCBI Old Locus TagBURCENK562V_C1269
Name
arnA2
Replicon ctg7180000002937
Genomic location 430096 - 431055 (- strand)
Partial sequence -> 3' end.
Partial sequence -> 5' end.
CommentIn PMID:27597847: arnT, arnB, arnC, arnA1, arnA2 and BURCENK562V_RS22180 ortholog BCAL1935 located in the arn gene cluster harbored significantly low frequencies of transposon insertions (TraDIS). They were therefore categorized as essential by the authors.

Cross-References

RefSeq WP_034176098.1
GI 736002180
GI 736002180
NCBI Locus Tag BURCENK562V_RS22185
NCBI Old Locus Tag BURCENK562V_C1269
RefSeq WP_034176098.1

Product

Feature Type CDS
Coding Frame 1
Product Name
UDP-4-amino-4-deoxy-L-arabinose formyltransferase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -3.17
Kyte-Doolittle Hydrophobicity Value -0.246
Molecular Weight (kDa) 35975.9
Isoelectric Point (pI) 6.32

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3SLG TRANSFERASE 06/24/11 Crystal structure of PbgP3 protein from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI 2.1 X-RAY DIFFRACTION 95.9

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001696 (652 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: arnA2

Human Homologs

References

PubMed ID: 22742453
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.
Williams GJ, Breazeale SD, Raetz CR, Naismith JH
J Biol Chem 2005 Jun 17;280(24):23000-8
PubMed ID: 15809294
A putative gene cluster for aminoarabinose biosynthesis is essential for Burkholderia cenocepacia viability.
Ortega XP, Cardona ST, Brown AR, Loutet SA, Flannagan RS, Campopiano DJ, Govan JR, Valvano MA
J Bacteriol 2007 May;189(9):3639-44
PubMed ID: 17337576
Candidate Essential Genes in Burkholderia cenocepacia J2315 Identified by Genome-Wide TraDIS.
Wong YC, Abd El Ghany M, Naeem R, Lee KW, Tan YC, Pain A, Nathan S
Front Microbiol 2016;7:1288
PubMed ID: 27597847