Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS28220 (tssK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
GCF_000333155.2|latest
Locus Tag
BURCENK562V_RS28220
NCBI Old Locus TagBURCENK562V_C6645
Name
tssK
Synonym: bcsO
Replicon ctg7180000002941
Genomic location 442826 - 444172 (- strand)
CommentPart of the T6SS gene cluster

Cross-References

RefSeq WP_006477098.1
GI 493523019
GI 493523019
NCBI Locus Tag BURCENK562V_RS28220
NCBI Old Locus Tag BURCENK562V_C6645
RefSeq WP_006477098.1

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssK
Product Name Confidence: Class 1
Synonyms type VI secretion protein
Evidence for Translation
Charge (pH 7) -10.92
Kyte-Doolittle Hydrophobicity Value -0.040
Molecular Weight (kDa) 49904.3
Isoelectric Point (pI) 5.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000363 (632 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: tssK

Human Homologs

References

A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia.
Aubert DF, Flannagan RS, Valvano MA
Infect Immun 2008 May;76(5):1979-91
PubMed ID: 18316384
TssK is a trimeric cytoplasmic protein interacting with components of both phage-like and membrane anchoring complexes of the type VI secretion system.
Zoued A, Durand E, Bebeacua C, Brunet YR, Douzi B, Cambillau C, Cascales E, Journet L
J Biol Chem 2013 Sep 20;288(38):27031-41
PubMed ID: 23921384
Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia.
Aubert DF, Hu S, Valvano MA
Microbiology 2015 Nov;161(11):2161-73
PubMed ID: 26364149