Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS34840 (ptwD4)

Cytoplasmic Membrane
Outer Membrane

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
Locus Tag
NCBI Old Locus TagBURCENK562V_C0108
Synonym: trwB
Replicon ctg7180000002935
Genomic location 75496 - 77415 (- strand)
CommentThis gene is part of the B. cenocepacia K56-2 plasmid-encoded ptw type IV secretion cluster.


RefSeq WP_034195737.1
GI 736050094
GI 736050094
NCBI Locus Tag BURCENK562V_RS34840
NCBI Old Locus Tag BURCENK562V_C0108
RefSeq WP_034195737.1


Feature Type CDS
Coding Frame 1
Product Name
type IV secretion system-coupling protein ptwD4
Product Name Confidence: Class 2
Synonyms type VI secretion protein
Evidence for Translation
Charge (pH 7) 0.07
Kyte-Doolittle Hydrophobicity Value -0.147
Molecular Weight (kDa) 72003.0
Isoelectric Point (pI) 7.02

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG005544 (40 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: ptwD4


PubMed ID: 27200362
Involvement of a plasmid-encoded type IV secretion system in the plant tissue watersoaking phenotype of Burkholderia cenocepacia.
Engledow AS, Medrano EG, Mahenthiralingam E, LiPuma JJ, Gonzalez CF.
J Bacteriol. 2004 Sep;186(18):6015-24.
PubMed ID: 15342570
Two type IV secretion systems with different functions in Burkholderia cenocepacia K56-2.
Zhang R, LiPuma JJ, Gonzalez CF.
Microbiology. 2009 Dec;155(Pt 12):4005-13.
PubMed ID: 19744991
A type IV secretion system contributes to intracellular survival and replication of Burkholderia cenocepacia.
Sajjan SU, Carmody LA, Gonzalez CF, LiPuma JJ.
Infect Immun. 2008 Dec;76(12):5447-55.
PubMed ID: 18824538