Burkholderia pseudomallei 1026b, BP1026B_II0539 (hmqE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei 1026b - Assembly GCF_000260515.1
GCF_000260515.1|latest
Locus Tag
BP1026B_II0539
NCBI Locus TagBP1026B_RS21270
Name
hmqE
Replicon chromosome 2
Genomic location 662452 - 663342 (+ strand)
CommentBelongs to the HMAQ biosynthesis operon hmqABCDEFG

Cross-References

RefSeq WP_004551371.1
GI
Entrez 12833197
NCBI Locus Tag BP1026B_RS21270
NCBI Old Locus Tag BP1026B_II0539
RefSeq WP_004551371.1

Product

Feature Type CDS
Coding Frame 1
Product Name
metallo-beta lactamase-related protein
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 1.69
Kyte-Doolittle Hydrophobicity Value -0.037
Molecular Weight (kDa) 32280.5
Isoelectric Point (pI) 7.27

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 27 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG017409 (462 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BP1026B_II0539
Search term: hmqE

Human Homologs

References

Burkholderia pseudomallei, B. thailandensis, and B. ambifaria produce 4-hydroxy-2-alkylquinoline analogues with a methyl group at the 3 position that is required for quorum-sensing regulation.
Vial L, Lépine F, Milot S, Groleau MC, Dekimpe V, Woods DE, Déziel E
J Bacteriol 2008 Aug;190(15):5339-52
PubMed ID: 18539738
Interplay between 4-Hydroxy-3-Methyl-2-Alkylquinoline and <i>N</i>-Acyl-Homoserine Lactone Signaling in a <i>Burkholderia cepacia</i> Complex Clinical Strain.
Chapalain A, Groleau MC, Le Guillouzer S, Miomandre A, Vial L, Milot S, Déziel E
Front Microbiol 2017;8:1021
PubMed ID: 28676791