Burkholderia cenocepacia J2315, BCAM2143 (bapA)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
NCBI Locus TagQU43_RS65080
Synonym: adhA
Replicon chromosome 2
Genomic location 2383411 - 2392185 (- strand)


RefSeq WP_006493867.1
GI 206563980
Entrez 6929737
GI 206563980
INSDC CAR56001.1
NCBI Locus Tag QU43_RS65080
NCBI Old Locus Tag BCAM2143
RefSeq WP_006493867.1,GeneID
UniParc UPI00017BA25F
UniProtKB Acc B4EFU0
UniRef100 UniRef100_B4EFU0
UniRef50 UniRef50_B4EFU0
UniRef90 UniRef90_B4EFU0


Feature Type CDS
Coding Frame 1
Product Name
Product Name Confidence: Class 1
Synonyms AdhA
Evidence for Translation
Charge (pH 7) -257.86
Kyte-Doolittle Hydrophobicity Value 0.069
Molecular Weight (kDa) 282269.0
Isoelectric Point (pI) 3.24

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 1
Outer Membrane Class 3
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 261 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG005411 (383 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: BCAM2143
Search term: bapA
Search term: BapA

Human Homologs


Cable pili and the 22-kilodalton adhesin are required for Burkholderia cenocepacia binding to and transmigration across the squamous epithelium.
Urban TA, Goldberg JB, Forstner JF, Sajjan US
Infect Immun 2005 Sep;73(9):5426-37
PubMed ID: 16113259
The AHL- and BDSF-dependent quorum sensing systems control specific and overlapping sets of genes in Burkholderia cenocepacia H111.
Schmid N, Pessi G, Deng Y, Aguilar C, Carlier AL, Grunau A, Omasits U, Zhang LH, Ahrens CH, Eberl L
PLoS One 2012;7(11):e49966
PubMed ID: 23185499
BapA, a large secreted protein required for biofilm formation and host colonization of Salmonella enterica serovar Enteritidis.
Latasa C, Roux A, Toledo-Arana A, Ghigo JM, Gamazo C, Penadés JR, Lasa I
Mol Microbiol 2005 Dec;58(5):1322-39
PubMed ID: 16313619
Identification of functions linking quorum sensing with biofilm formation in Burkholderia cenocepacia H111.
Inhülsen S, Aguilar C, Schmid N, Suppiger A, Riedel K, Eberl L
Microbiologyopen 2012 Jun;1(2):225-42
PubMed ID: 22950027