Burkholderia cenocepacia J2315, BCAL1887 (ndk)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL1887
NCBI Locus Tag	QU43_RS45980
Name	ndk
Replicon	chromosome 1
Genomic location	2083639 - 2084064 (- strand)

Cross-References

RefSeq	WP_006478674.1
GI	206560250
Entrez	6932096
GI	206560250
INSDC	CAR52187.1
NCBI Locus Tag	QU43_RS45980
NCBI Old Locus Tag	BCAL1887
RefSeq	WP_006478674.1,GeneID
UniParc	UPI00002F8734
UniProtKB Acc	B4EAX2
UniProtKB ID	NDK_BURCJ
UniRef100	UniRef100_Q1BGX7
UniRef50	UniRef50_Q5WGT0
UniRef90	UniRef90_Q2SWE7

Product

Feature Type	CDS
Coding Frame	1
Product Name	nucleoside diphosphate kinase
Synonyms
Evidence for Translation
Charge (pH 7)	-1.29
Kyte-Doolittle Hydrophobicity Value	0.055
Molecular Weight (kDa)	15335.5
Isoelectric Point (pI)	6.26

Subcellular localization

Individual Mappings	Localization Confidence PMID Extracellular Class 3 20472543 Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
4EK2	TRANSFERASE	04/09/12	The structure of nucleoside diphosphate kinase (NDK) from Burkholderia thailandensis bound to deoxyadenosine monophosphate	BURKHOLDERIA THAILANDENSIS	2.0	X-RAY DIFFRACTION	94.3
4HR2	TRANSFERASE	10/26/12	Structure of nucleoside diphosphate kinase (NDK) from Burkholderia thailandensis bound to ADP	BURKHOLDERIA THAILANDENSIS	1.95	X-RAY DIFFRACTION	94.3
4DUT	TRANSFERASE	02/22/12	The structure of nucleoside diphosphate kinase (NDK) from Burkholderia thailandensis	BURKHOLDERIA THAILANDENSIS	2.5	X-RAY DIFFRACTION	94.3

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 598 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG001652 (653 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL1887 Search term: ndk Search term: nucleoside diphosphate kinase

Human Homologs

Ensembl 97, assembly GRCh38.p12

ENSP00000219302 NME/NM23 nucleoside diphosphate kinase 3 [Source:HGNC Symbol;Acc:HGNC:7851] E-value: 5.9e-23 Percent Identity: 42.4

References