Burkholderia cenocepacia J2315, BCAL0509 (metK)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL0509
NCBI Locus Tag	QU43_RS39110
Name	metK
Replicon	chromosome 1
Genomic location	560648 - 561835 (+ strand)

Cross-References

RefSeq	WP_006482984.1
GI	206558910
Entrez	6931013
GI	206558910
INSDC	CAR50819.1
NCBI Locus Tag	QU43_RS39110
NCBI Old Locus Tag	BCAL0509
RefSeq	WP_006482984.1,GeneID
UniParc	UPI00017B8FD9
UniProtKB Acc	B4E800
UniProtKB ID	METK_BURCJ
UniRef100	UniRef100_B4E800
UniRef50	UniRef50_P13444
UniRef90	UniRef90_Q146W0

Product

Feature Type	CDS
Coding Frame	1
Product Name	S-adenosylmethionine synthetase
Synonyms
Evidence for Translation
Charge (pH 7)	-12.43
Kyte-Doolittle Hydrophobicity Value	-0.166
Molecular Weight (kDa)	42693.9
Isoelectric Point (pI)	4.82

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
3IML	TRANSFERASE	08/10/09	Crystal Structure Of S-Adenosylmethionine Synthetase From Burkholderia Pseudomallei	BURKHOLDERIA PSEUDOMALLEI	2.35	X-RAY DIFFRACTION	95.2

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 582 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG002906 (655 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL0509 Search term: metK Search term: S-adenosylmethionine synthetase

Human Homologs

Ensembl 97, assembly GRCh38.p12

ENSP00000361287 methionine adenosyltransferase 1A [Source:HGNC Symbol;Acc:HGNC:6903] E-value: 1.5e-111 Percent Identity: 55.3

References