Burkholderia cenocepacia J2315, BCAL0508 (lpxL)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL0508
NCBI Locus TagQU43_RS39105
Name
lpxL
Replicon chromosome 1
Genomic location 559498 - 560382 (- strand)

Cross-References

RefSeq WP_006482982.1
GI 206558909
Entrez 6933493
GI 206558909
INSDC CAR50818.1
NCBI Locus Tag QU43_RS39105
NCBI Old Locus Tag BCAL0508
RefSeq WP_006482982.1,GeneID
UniParc UPI00017B8FD8
UniProtKB Acc B4E7Z9
UniProtKB ID B4E7Z9_BURCJ
UniRef100 UniRef100_A0A095DRF3
UniRef50 UniRef50_B3R8K0
UniRef90 UniRef90_B1K0F3

Product

Feature Type CDS
Coding Frame 1
Product Name
lipid A biosynthesis myristoyl acyltransferase LpxL
Product Name Confidence: Class 1
Synonyms lipid A biosynthesis lauroyl acyltransferase
Evidence for Translation
Charge (pH 7) 11.83
Kyte-Doolittle Hydrophobicity Value -0.300
Molecular Weight (kDa) 33754.7
Isoelectric Point (pI) 9.93

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 237 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002907 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL0508
Search term: lpxL

Human Homologs

References

The LpxL acyltransferase is required for normal growth and penta-acylation of lipid A in Burkholderia cenocepacia.
Fathy Mohamed Y, Hamad M, Ortega XP, Valvano MA
Mol Microbiol 2017 Apr;104(1):144-162
PubMed ID: 28085228