Burkholderia cenocepacia J2315, BCAL0351 (tssM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL0351
NCBI Locus TagQU43_RS38290
Name
tssM
Synonym: icmF
Replicon chromosome 1
Genomic location 378936 - 382880 (- strand)
CommentPart of the T6SS gene cluster

Cross-References

RefSeq WP_012492310.1
GI 206558757
Entrez 6930895
GI 206558757
INSDC CAR50661.1
NCBI Locus Tag QU43_RS38290
NCBI Old Locus Tag BCAL0351
RefSeq WP_012492310.1,GeneID
UniParc UPI00017B912F
UniProtKB Acc B4E6S3
UniProtKB ID B4E6S3_BURCJ
UniRef100 UniRef100_U1XBB7
UniRef50 UniRef50_Q8XRR8
UniRef90 UniRef90_Q39K40

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssM
Product Name Confidence: Class 1
Synonyms putative type VI secretion system protein TssM
Evidence for Translation
Charge (pH 7) 10.16
Kyte-Doolittle Hydrophobicity Value -0.227
Molecular Weight (kDa) 143200.1
Isoelectric Point (pI) 9.28

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 102 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000378 (652 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL0351
Search term: tssM

Human Homologs

References

A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia.
Aubert DF, Flannagan RS, Valvano MA
Infect Immun 2008 May;76(5):1979-91
PubMed ID: 18316384
Towards a structural comprehension of bacterial type VI secretion systems: characterization of the TssJ-TssM complex of an Escherichia coli pathovar.
Felisberto-Rodrigues C, Durand E, Aschtgen MS, Blangy S, Ortiz-Lombardia M, Douzi B, Cambillau C, Cascales E
PLoS Pathog 2011 Nov;7(11):e1002386
PubMed ID: 22102820
Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia.
Aubert DF, Hu S, Valvano MA
Microbiology 2015 Nov;161(11):2161-73
PubMed ID: 26364149