Strain |
Burkholderia cenocepacia J2315
GCF_000009485.1|latest |
Locus Tag |
BCAM2761
|
NCBI Locus Tag | QU43_RS68265 |
Name |
cblA
|
Replicon | chromosome 2 |
Genomic location | 3125238 - 3125738 (- strand) |
RefSeq | WP_006485048.1 |
GI | 206564599 |
Entrez | 6930409 |
GI | 206564599 |
INSDC | CAR56625.1 |
NCBI Locus Tag | QU43_RS68265 |
NCBI Old Locus Tag | BCAM2761 |
RefSeq | WP_006485048.1,GeneID |
UniParc | UPI00000B2588 |
UniProtKB Acc | B4ELG0 |
UniProtKB ID | B4ELG0_BURCJ |
UniRef100 | UniRef100_B4ELG0 |
UniRef50 | UniRef50_B4ELG0 |
UniRef90 | UniRef90_B4ELG0 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
giant cable pilus
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | -1.02 |
Kyte-Doolittle Hydrophobicity Value | 0.234 |
Molecular Weight (kDa) | 17047.5 |
Isoelectric Point (pI) | 5.08 |
Individual Mappings | |
Additional evidence for subcellular localization |
Source 1 | |
Database | BGD |
Category | Cable pili |
Evidence |
ECO:0000315
mutant phenotype evidence used in manual assertion
|
Host Organism | Homo sapiens |
Notes | Cable pili are necessary for inducing A549 transformed human epithelial lung cell death via apoptosis |
Reference | 17537663 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 11 genera
|
Burkholderia Ortholog Group |
BG005919 (93 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BCAM2761
Search term: cblA
Search term: giant cable pilus
|
The emergence of a highly transmissible lineage of cbl+ Pseudomonas (Burkholderia) cepacia causing CF centre epidemics in North America and Britain.
Sun L, Jiang RZ, Steinbach S, Holmes A, Campanelli C, Forstner J, Sajjan U, Tan Y, Riley M, Goldstein R
Nat Med 1995 Jul;1(7):661-6
PubMed ID: 7585148
|
Erratum in: J Bacteriol. 2009 Apr;191(8):2907.
The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.
J Bacteriol. 2009 Jan;191(1):261-77.
PubMed ID: 18931103
|
Adherence and autoaggregation phenotypes of a Burkholderia cenocepacia cable pilus mutant.
Tomich M, Mohr CD
FEMS Microbiol Lett 2003 Nov 21;228(2):287-97
PubMed ID: 14638436
|
Cable pili and the 22-kilodalton adhesin are required for Burkholderia cenocepacia binding to and transmigration across the squamous epithelium.
Urban TA, Goldberg JB, Forstner JF, Sajjan US
Infect Immun 2005 Sep;73(9):5426-37
PubMed ID: 16113259
|
Identification and molecular analysis of cable pilus biosynthesis genes in Burkholderia cepacia.
Sajjan US, Xie H, Lefebre MD, Valvano MA, Forstner JF
Microbiology 2003 Apr;149(Pt 4):961-971
PubMed ID: 12686638
|
Pilus-mediated epithelial cell death in response to infection with Burkholderia cenocepacia.
Cheung KJ Jr, Li G, Urban TA, Goldberg JB, Griffith A, Lu F, Burns JL
Microbes Infect 2007 Jun;9(7):829-37
PubMed ID: 17537663
|