Burkholderia cenocepacia J2315, BCAM2232 (pchD)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAM2232
NCBI Locus Tag	QU43_RS65525
Name	pchD
Replicon	chromosome 2
Genomic location	2502352 - 2504001 (+ strand)

Cross-References

RefSeq	WP_012493510.1
GI	206564067
Entrez	6930593
GI	206564067
INSDC	CAR56089.1
NCBI Locus Tag	QU43_RS65525
NCBI Old Locus Tag	BCAM2232
RefSeq	WP_012493510.1,GeneID
UniParc	UPI00017BA020
UniProtKB Acc	B4EGG3
UniProtKB ID	B4EGG3_BURCJ
UniRef100	UniRef100_A0A0D1C976
UniRef50	UniRef50_Q0S7A8
UniRef90	UniRef90_G7HSM8

Product

Feature Type	CDS
Coding Frame	1
Product Name	putative pyochelin biosynthetic protein PchD
Synonyms
Evidence for Translation
Charge (pH 7)	-2.34
Kyte-Doolittle Hydrophobicity Value	-0.053
Molecular Weight (kDa)	59537.2
Isoelectric Point (pI)	6.69

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 593 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG001594 (514 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAM2232 Search term: pchD Search term: putative pyochelin biosynthetic protein PchD

Human Homologs

Ensembl 97, assembly GRCh38.p12

ENSP00000316924 acyl-CoA synthetase short chain family member 1 [Source:HGNC Symbol;Acc:HGNC:16091] E-value: 3.7e-20 Percent Identity: 23.3

References

Dihydroaeruginoic acid synthetase and pyochelin synthetase, products of the pchEF genes, are induced by extracellular pyochelin in Pseudomonas aeruginosa. Reimmann C, Serino L, Beyeler M, Haas D Microbiology 1998 Nov;144 ( Pt 11):3135-48 PubMed ID: 9846750

Erratum in: J Bacteriol. 2009 Apr;191(8):2907. The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients. J Bacteriol. 2009 Jan;191(1):261-77. PubMed ID: 18931103