Burkholderia cenocepacia J2315, BCAM2224 (fptA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM2224
NCBI Locus TagQU43_RS65490
Name
fptA
Replicon chromosome 2
Genomic location 2484354 - 2486537 (- strand)

Cross-References

RefSeq WP_006486761.1
GI 206564061
Entrez 6929810
GI 206564061
INSDC CAR56082.1
NCBI Locus Tag QU43_RS65490
NCBI Old Locus Tag BCAM2224
RefSeq WP_006486761.1,GeneID
UniParc UPI00017B9FE0
UniProtKB Acc B4EGF6
UniProtKB ID B4EGF6_BURCJ
UniRef100 UniRef100_U1ZI91
UniRef50 UniRef50_P42512
UniRef90 UniRef90_U1ZI91

Product

Feature Type CDS
Coding Frame 1
Product Name
putative pyochelin receptor protein FptA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 7.07
Kyte-Doolittle Hydrophobicity Value -0.292
Molecular Weight (kDa) 79332.1
Isoelectric Point (pI) 8.84

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 258 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG006690 (385 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM2224
Search term: fptA

Human Homologs

References

Dihydroaeruginoic acid synthetase and pyochelin synthetase, products of the pchEF genes, are induced by extracellular pyochelin in Pseudomonas aeruginosa.
Reimmann C, Serino L, Beyeler M, Haas D
Microbiology 1998 Nov;144 ( Pt 11):3135-48
PubMed ID: 9846750
Erratum in: J Bacteriol. 2009 Apr;191(8):2907.
The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.
J Bacteriol. 2009 Jan;191(1):261-77.
PubMed ID: 18931103
Importance of the ornibactin and pyochelin siderophore transport systems in Burkholderia cenocepacia lung infections.
Visser MB, Majumdar S, Hani E, Sokol PA
Infect Immun 2004 May;72(5):2850-7
PubMed ID: 15102796