Burkholderia cenocepacia J2315, BCAL0790

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:0019752	carboxylic acid metabolic process	ISM Inferred from Sequence Model Term mapped from: InterPro:PS00815	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0009098	leucine biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:TIGR00970	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	ISM Inferred from Sequence Model Term mapped from: InterPro:PS00815	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0003852	2-isopropylmalate synthase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:TIGR00970	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0003824	catalytic activity	ISM Inferred from Sequence Model Term mapped from: InterPro:G3DSA:3.20.20.70	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
MetaCyc		3-methylbutanol biosynthesis (engineered)	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
KEGG	bcj01110	Biosynthesis of secondary metabolites	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	bcj00290	Valine, leucine and isoleucine biosynthesis	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG (InterPro)	00290	Valine, leucine and isoleucine biosynthesis	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
KEGG	bcj01210	2-Oxocarboxylic acid metabolism	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	bcj01230	Biosynthesis of amino acids	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	bcj00620	Pyruvate metabolism	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG (InterPro)	00620	Pyruvate metabolism	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
KEGG	bcj01100	Metabolic pathways	73.0+/03-31, Mar 15	ECO:0000249 sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
TIGRFAM	TIGR00970	leuA_yeast: 2-isopropylmalate synthase	IPR005668	2-isopropylmalate synthase	5	439	1.5E-213
ProSitePatterns	PS00816	Alpha-isopropylmalate and homocitrate synthases signature 2.	IPR002034	Alpha-isopropylmalate/homocitrate synthase, conserved site	241	254	-
SMART	SM00917		IPR013709	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	420	538	0.0016
SUPERFAMILY	SSF110921		IPR036230	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain superfamily	493	536	2.35E-5
Gene3D	G3DSA:3.20.20.70		IPR013785	Aldolase-type TIM barrel	9	374	1.3E-155
Pfam	PF00682	HMGL-like	IPR000891	Pyruvate carboxyltransferase	32	311	9.1E-74
SUPERFAMILY	SSF89000				386	436	1.45E-8
SUPERFAMILY	SSF51569				20	328	4.76E-99
ProSiteProfiles	PS50991	Pyruvate carboxyltransferase domain.	IPR000891	Pyruvate carboxyltransferase	31	305	17.838
ProSitePatterns	PS00815	Alpha-isopropylmalate and homocitrate synthases signature 1.	IPR002034	Alpha-isopropylmalate/homocitrate synthase, conserved site	38	54	-
Hamap	MF_00572	2-isopropylmalate synthase [leuA].	IPR005668	2-isopropylmalate synthase	6	539	49.523
Gene3D	G3DSA:3.30.160.270				375	537	3.5E-24
CDD	cd07942	DRE_TIM_LeuA	IPR039371	LeuA, N-terminal catalytic TIM barrel domain	30	313	0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.