Burkholderia dolosa AU0158, AK34_RS25965 (pacL)

Cytoplasmic Membrane
Outer Membrane
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Annotation Updates

Date Description Acknowledgements
Apr 30, 2018 New gene name: pacL. New product name: PacL. New product name synonym: putative 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase. New product name confidence: Class 2. New PubMed ID: 21296885. New PubMed ID: 18776009. New comment: in E coli, paaZ encodes a bifunctional protein consisting of an N-terminal NADP-dependent aldehyde dehydrogenase domain and a C-terminal MaoC-like (R)-specific enoyl-CoA hydratase domain. In Burkholderia genomes, a gene incorrectly annotated as paaZ (e.g WQ49_RS11500) encodes only one of the two domains found in E.coli paaZ (the domain with semialdehyde dehydrogenase activity) and so is renamed PacL (PMID:21296885) but was also referred to as PaaZ-ALDH in the manuscript. In the same study , a separate A. aromaticum, protein (UniProtKB:Q5P232) with the (R)-hydratase activity was annotated as Ech-Aa and the Burkholderia ortholog was annotated as PaaZ-ECH.. Annotation transferred from: UniProtKB:Q5P3J4. Geoff Winsor, Simon Fraser University. Transferred annotation from the B. cenocepacia annotation provided by D. Lavellee and S. Cardona.