Burkholderia pseudomallei K96243, BPSS1722 (mdh)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Biological Process | GO:0005975 | carbohydrate metabolic process |
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.90.110.10
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0016615 | malate dehydrogenase activity |
Inferred from Sequence Model
Term mapped from: InterPro:MF_01517
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0019752 | carboxylic acid metabolic process |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000102
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0006108 | malate metabolic process |
Inferred from Sequence Model
Term mapped from: InterPro:MF_01517
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0055114 | oxidation-reduction process |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000102
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000102
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0003824 | catalytic activity |
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.90.110.10
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0016491 | oxidoreductase activity |
Inferred from Sequence Model
Term mapped from: InterPro:PF00056
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
Pathways
| Database | Xref | Pathway | Version | Evidence | PMID |
|---|---|---|---|---|---|
| KEGG | bps00630 | Glyoxylate and dicarboxylate metabolism | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| MetaCyc | superpathway of glyoxylate cycle and fatty acid degradation | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| MetaCyc | reductive TCA cycle II | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG (InterPro) | 00620 | Pyruvate metabolism | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
|
| KEGG | bps01130 | Biosynthesis of antibiotics | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bps00620 | Pyruvate metabolism | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bps00270 | Cysteine and methionine metabolism | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| MetaCyc | partial TCA cycle (obligate autotrophs) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| MetaCyc | TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG | bps01200 | Carbon metabolism | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bps00020 | Citrate cycle (TCA cycle) | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| MetaCyc | formaldehyde assimilation I (serine pathway) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| MetaCyc | methylaspartate cycle | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| MetaCyc | anaerobic energy metabolism (invertebrates, cytosol) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG (InterPro) | 00020 | Citrate cycle (TCA cycle) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
|
| KEGG (InterPro) | 00710 | Carbon fixation in photosynthetic organisms | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
|
| MetaCyc | TCA cycle II (plants and fungi) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG | bps01120 | Microbial metabolism in diverse environments | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG (InterPro) | 00270 | Cysteine and methionine metabolism | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
|
| KEGG | bps01110 | Biosynthesis of secondary metabolites | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bps00710 | Carbon fixation in photosynthetic organisms | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bps01100 | Metabolic pathways | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| MetaCyc | C4 photosynthetic carbon assimilation cycle, NAD-ME type | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG (InterPro) | 00720 | Carbon fixation pathways in prokaryotes | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
|
| KEGG (InterPro) | 00630 | Glyoxylate and dicarboxylate metabolism | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
|
| KEGG (InterPro) | 00680 | Methane metabolism | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
|
| KEGG | bps00680 | Methane metabolism | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| Hamap | MF_01517 | Malate dehydrogenase [mdh]. | IPR010945 | Malate dehydrogenase, type 2 | 2 | 326 | 55.917 |
| Pfam | PF00056 | lactate/malate dehydrogenase, NAD binding domain | IPR001236 | Lactate/malate dehydrogenase, N-terminal | 7 | 153 | 2.9E-37 |
| Gene3D | G3DSA:3.90.110.10 | IPR015955 | Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal | 156 | 327 | 1.8E-60 | |
| Gene3D | G3DSA:3.40.50.720 | 1 | 155 | 3.8E-61 | |||
| SUPERFAMILY | SSF51735 | IPR036291 | NAD(P)-binding domain superfamily | 6 | 156 | 4.27E-44 | |
| Pfam | PF02866 | lactate/malate dehydrogenase, alpha/beta C-terminal domain | IPR022383 | Lactate/malate dehydrogenase, C-terminal | 158 | 321 | 4.0E-31 |
| CDD | cd01338 | MDH_choloroplast_like | 4 | 324 | 0.0 | ||
| SUPERFAMILY | SSF56327 | IPR015955 | Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal | 158 | 326 | 1.02E-58 | |
| PIRSF | PIRSF000102 | IPR001557 | L-lactate/malate dehydrogenase | 2 | 324 | 9.7E-63 | |
| TIGRFAM | TIGR01759 | MalateDH-SF1: malate dehydrogenase | IPR010945 | Malate dehydrogenase, type 2 | 5 | 320 | 9.9E-144 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.