Burkholderia pseudomallei K96243, BPSS1624 (bpscJ2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1624
Name
bpscJ2
Synonym: sctJ
Replicon chromosome 2
Genomic location 2198712 - 2199566 (+ strand)
CommentThis gene is part of the type III secretion system T3SS-2 locus found in B. pseudomallei. B. pseudomallei T3SS-1 and T3SS-2, but not T3SS-3 contribute to pathogenicity in Solanum lycopersicum (tomato) but not human monocytic cell line THP-1. (PMID:20109238).

Cross-References

RefSeq YP_111632.1
GI 53722647
Entrez 3095191
GI 53722647
INSDC CAH39099.1
NCBI Locus Tag BPSS1624
RefSeq YP_111632.1,GeneID
UniParc UPI000043BD7B
UniProtKB Acc Q63JU0
UniProtKB ID Q63JU0_BURPS
UniRef100 UniRef100_A3P7C5
UniRef50 UniRef50_Q3JLH0
UniRef90 UniRef90_A3P7C5

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion system inner membrane ring component BpscJ2 (T3SS-2)
Product Name Confidence: Class 2
Synonyms type III secretion protein
Evidence for Translation
Charge (pH 7) 11.62
Kyte-Doolittle Hydrophobicity Value 0.064
Molecular Weight (kDa) 29602.9
Isoelectric Point (pI) 10.35

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
T3SS
Note: This is based on PSORTb V3.0 secondary localization prediction
 Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 146 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003799 (574 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1624
Search term: bpscJ2

Human Homologs

References

Type III secretion system cluster 3 is required for maximal virulence of Burkholderia pseudomallei in a hamster infection model.
Warawa J, Woods DE
FEMS Microbiol Lett 2005 Jan 1;242(1):101-8
PubMed ID: 15621426
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152