Burkholderia pseudomallei K96243, BPSS0516 (tssH-6)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS0516
Name
tssH-6
Synonym: tssB-4
Replicon chromosome 2
Genomic location 703088 - 703636 (+ strand)
CommentGene is part of a cluster known as the type VI secretion system gene cluster tss-4 used in much of the early P. pseudomallei literature (PMID:17660433) but later referred to as T6SS-2 cluster later (PMID:22007185)
CommentGene is part of a cluster known as the type VI secretion system gene cluster tss-6 used in much of the early P. pseudomallei literature (PMID:17660433) but later referred to as T6SS-3 cluster later (PMID:22007185)

Cross-References

RefSeq YP_110537.1
GI 53721552
Entrez 3096828
GI 53721552
INSDC CAH37973.1
NCBI Locus Tag BPSS0516
RefSeq YP_110537.1,GeneID
UniParc UPI000043B94F
UniProtKB Acc Q63MY2
UniProtKB ID Q63MY2_BURPS
UniRef100 UniRef100_C4I8K9
UniRef50 UniRef50_L7ZP21
UniRef90 UniRef90_Q2T404

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssH-6
Product Name Confidence: Class 2
Synonyms type VI secretion system protein TssB-4
hypothetical protein
Evidence for Translation
Charge (pH 7) -15.51
Kyte-Doolittle Hydrophobicity Value -0.512
Molecular Weight (kDa) 20120.3
Isoelectric Point (pI) 4.21

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 108 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019178 (321 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS0516
Search term: tssH-6

Human Homologs

References

In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS
Microbiology 2007 Aug;153(Pt 8):2689-2699
PubMed ID: 17660433
Strategies for Intracellular Survival of Burkholderia pseudomallei.
Allwood EM, Devenish RJ, Prescott M, Adler B, Boyce JD
Front Microbiol 2011;2:170
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA, Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D
Mol Microbiol 2007 Jun;64(6):1466-85
PubMed ID: 17555434