Burkholderia pseudomallei K96243, BPSL2473 (thyA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006231 dTMP biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00008
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004799 thymidylate synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00008
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Pathways

Database Xref Pathway Version Evidence PMID
MetaCyc pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis I InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc pyrimidine deoxyribonucleotides biosynthesis from CTP InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc pyrimidine deoxyribonucleosides salvage InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG (InterPro) 00240 Pyrimidine metabolism InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis IV InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc folate transformations II InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG (InterPro) 00670 One carbon pool by folate InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bps00670 One carbon pool by folate 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis II InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bps00240 Pyrimidine metabolism 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bps01100 Metabolic pathways 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PRINTS PR00108 Thymidylate synthase family signature IPR000398 Thymidylate synthase 161 180 6.8E-26
SUPERFAMILY SSF55831 IPR036926 Thymidylate synthase/dCMP hydroxymethylase superfamily 1 323 1.13E-94
TIGRFAM TIGR03284 thym_sym: thymidylate synthase IPR000398 Thymidylate synthase 153 323 2.8E-34
Hamap MF_00008 Thymidylate synthase [thyA]. IPR000398 Thymidylate synthase 1 323 33.705
Gene3D G3DSA:3.30.572.10 IPR036926 Thymidylate synthase/dCMP hydroxymethylase superfamily 1 323 2.0E-124
PRINTS PR00108 Thymidylate synthase family signature IPR000398 Thymidylate synthase 187 202 6.8E-26
PRINTS PR00108 Thymidylate synthase family signature IPR000398 Thymidylate synthase 42 63 6.8E-26
CDD cd00351 TS_Pyrimidine_HMase IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain 3 265 1.02991E-82
PRINTS PR00108 Thymidylate synthase family signature IPR000398 Thymidylate synthase 245 262 6.8E-26
Pfam PF00303 Thymidylate synthase IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain 2 323 5.5E-83
PRINTS PR00108 Thymidylate synthase family signature IPR000398 Thymidylate synthase 207 233 6.8E-26

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.