Burkholderia pseudomallei K96243, BPSL2304 (folD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0055114 oxidation-reduction process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00085
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00767
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00085
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00767
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0055114 oxidation-reduction process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00085
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00085
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Pathways

Database Xref Pathway Version Evidence PMID
KEGG (InterPro) 00720 Carbon fixation pathways in prokaryotes InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG (InterPro) 00670 One carbon pool by folate InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bps01100 Metabolic pathways 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bps01200 Carbon metabolism 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc purine nucleobases degradation II (anaerobic) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc folate transformations II InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc formaldehyde oxidation VII (THF pathway) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bps00670 One carbon pool by folate 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc folate transformations I InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc L-histidine degradation III InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc formate assimilation into 5,10-methylenetetrahydrofolate InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bps01120 Microbial metabolism in diverse environments 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 123 281 1.3E-70
PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase 203 232 2.4E-85
PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase 74 101 2.4E-85
ProSitePatterns PS00766 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. IPR020867 Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site 75 100 -
PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase 33 55 2.4E-85
SUPERFAMILY SSF53223 1 121 6.43E-40
ProSitePatterns PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. IPR020867 Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site 259 267 -
PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase 238 254 2.4E-85
SUPERFAMILY SSF51735 IPR036291 NAD(P)-binding domain superfamily 122 280 4.04E-53
Gene3D G3DSA:3.40.50.720 6 258 3.9E-112
PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase 154 174 2.4E-85
Pfam PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 5 120 4.3E-40
PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase 255 273 2.4E-85
Hamap MF_01576 Bifunctional protein FolD [folD]. IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase 3 282 38.967
PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase 109 130 2.4E-85
CDD cd01080 NAD_bind_m-THF_DH_Cyclohyd IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 115 275 1.27841E-90
Gene3D G3DSA:3.40.50.10860 8 276 3.9E-112

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.