Burkholderia pseudomallei K96243, BPSL2127 (guaA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006164 purine nucleotide biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd01997
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016462 pyrophosphatase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS51553
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016462 pyrophosphatase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS51553
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006177 GMP biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd01997
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd01997
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd01997
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003922 GMP synthase (glutamine-hydrolyzing) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd01997
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006177 GMP biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd01997
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003922 GMP synthase (glutamine-hydrolyzing) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd01997
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006164 purine nucleotide biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd01997
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Pathways

Database Xref Pathway Version Evidence PMID
KEGG bps00230 Purine metabolism 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bps01100 Metabolic pathways 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG (InterPro) 00230 Purine metabolism InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG (InterPro) 00983 Drug metabolism - other enzymes InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc guanosine ribonucleotides <i>de novo</i> biosynthesis InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
CDD cd01742 GATase1_GMP_Synthase IPR004739 GMP synthase, glutamine amidotransferase 13 201 4.04641E-88
CDD cd01997 GMP_synthase_C IPR001674 GMP synthase, C-terminal 233 546 0.0
Gene3D G3DSA:3.30.300.10 409 547 2.0E-47
Hamap MF_00344 GMP synthase [glutamine-hydrolyzing] [guaA]. IPR022955 GMP synthase 10 547 54.0
TIGRFAM TIGR00888 guaA_Nterm: GMP synthase (glutamine-hydrolyzing), N-terminal domain IPR004739 GMP synthase, glutamine amidotransferase 13 207 9.7E-69
Pfam PF00117 Glutamine amidotransferase class-I IPR017926 Glutamine amidotransferase 15 203 1.1E-31
SUPERFAMILY SSF52402 200 422 1.94E-58
ProSiteProfiles PS51553 GMP synthetase ATP pyrophosphatase (GMPS ATP-PPase) domain profile. IPR025777 GMP synthetase ATP pyrophosphatase domain 211 403 83.877
TIGRFAM TIGR00884 guaA_Cterm: GMP synthase (glutamine-hydrolyzing), C-terminal domain IPR001674 GMP synthase, C-terminal 216 547 1.2E-139
Gene3D G3DSA:3.40.50.620 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold 213 408 4.3E-74
SUPERFAMILY SSF54810 408 547 9.02E-44
ProSiteProfiles PS51273 Glutamine amidotransferase type 1 domain profile. IPR017926 Glutamine amidotransferase 12 210 31.151
Pfam PF02540 NAD synthase IPR022310 NAD/GMP synthase 224 257 1.6E-6
Pfam PF00958 GMP synthase C terminal domain IPR001674 GMP synthase, C-terminal 461 546 5.1E-40
SUPERFAMILY SSF52317 IPR029062 Class I glutamine amidotransferase-like 7 240 8.44E-55
Gene3D G3DSA:3.40.50.880 IPR029062 Class I glutamine amidotransferase-like 12 208 1.2E-50

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.