Burkholderia pseudomallei K96243, BPSL2009 (alaS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2009
Name
alaS
Replicon chromosome 1
Genomic location 2395633 - 2398257 (- strand)

Cross-References

RefSeq YP_108607.1
GI 53719621
Entrez 3094503
GI 53719621
INSDC CAH36008.1
NCBI Locus Tag BPSL2009
RefSeq YP_108607.1,GeneID
UniParc UPI000043B200
UniProtKB Acc Q63TF9
UniProtKB ID SYA_BURPS
UniRef100 UniRef100_A3MJ36
UniRef50 UniRef50_Q39HB7
UniRef90 UniRef90_A0K6N4

Product

Feature Type CDS
Coding Frame 1
Product Name
alanyl-tRNA synthetase
Synonyms
Evidence for Translation
Charge (pH 7) -12.86
Kyte-Doolittle Hydrophobicity Value -0.231
Molecular Weight (kDa) 94694.4
Isoelectric Point (pI) 6.14

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 667 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001236 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2009
Search term: alaS

Human Homologs

Ensembl 97, assembly GRCh38.p12
alanyl-tRNA synthetase [Source:HGNC Symbol;Acc:HGNC:20]
E-value: 2.3e-125
Percent Identity: 36.3

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268