Burkholderia pseudomallei K96243, BPSL1911 (typA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL1911
Name
typA
Replicon chromosome 1
Genomic location 2276550 - 2278376 (- strand)

Cross-References

RefSeq YP_108511.1
GI 53719525
Entrez 3091717
GI 53719525
INSDC CAH35911.1
NCBI Locus Tag BPSL1911
RefSeq YP_108511.1,GeneID
UniParc UPI000043B1A2
UniProtKB Acc Q63TQ5
UniProtKB ID Q63TQ5_BURPS
UniRef100 UniRef100_A0A095Q5R8
UniRef50 UniRef50_P72749
UniRef90 UniRef90_Q39H23

Product

Feature Type CDS
Coding Frame 1
Product Name
GTP-binding protein
Synonyms
Evidence for Translation
Charge (pH 7) -14.88
Kyte-Doolittle Hydrophobicity Value -0.255
Molecular Weight (kDa) 67497.5
Isoelectric Point (pI) 5.20

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001335 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL1911
Search term: typA

Human Homologs

Ensembl 97, assembly GRCh38.p12
elongation factor like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:25789]
E-value: 3.5e-24
Percent Identity: 43.0
Ensembl 97, assembly GRCh38.p12
elongation factor like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:25789]
E-value: 3.5e-24
Percent Identity: 43.0

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268