Burkholderia pseudomallei K96243, BPSL1513 (ispG)

Gene Feature Overview

Strain	Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1 GCF_000011545.1|latest
Locus Tag	BPSL1513
Name	ispG
Replicon	chromosome 1
Genomic location	1751569 - 1752819 (+ strand)

Cross-References

RefSeq	YP_108133.1
GI	53719147
Entrez	3094863
GI	53719147
INSDC	CAH35514.1
NCBI Locus Tag	BPSL1513
RefSeq	YP_108133.1,GeneID
UniParc	UPI000043B02A
UniProtKB Acc	Q63UT3
UniProtKB ID	ISPG_BURPS
UniRef100	UniRef100_A3MK75
UniRef50	UniRef50_Q72H18
UniRef90	UniRef90_A3MK75

Product

Feature Type	CDS
Coding Frame	1
Product Name	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
Synonyms
Evidence for Translation
Charge (pH 7)	-2.49
Kyte-Doolittle Hydrophobicity Value	-0.047
Molecular Weight (kDa)	44461.5
Isoelectric Point (pI)	6.41

Subcellular localization

Individual Mappings	Localization Confidence PMID Extracellular Class 1 quantitative mass spectrometry evidence 25635268 Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 515 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG001649 (653 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BPSL1513 Search term: ispG Search term: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase

Human Homologs

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants. Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM Mol Cell Proteomics 2015 Apr;14(4):905-16 PubMed ID: 25635268