Burkholderia pseudomallei K96243, BPSL0797 (pykA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Molecular Function | GO:0003824 | catalytic activity |
Inferred from Sequence Model
Term mapped from: InterPro:SSF51621
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0004743 | pyruvate kinase activity |
Inferred from Sequence Model
Term mapped from: InterPro:PF00224
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0006096 | glycolytic process |
Inferred from Sequence Model
Term mapped from: InterPro:PF00224
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0030955 | potassium ion binding |
Inferred from Sequence Model
Term mapped from: InterPro:PF00224
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0000287 | magnesium ion binding |
Inferred from Sequence Model
Term mapped from: InterPro:PF00224
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
Pathways
| Database | Xref | Pathway | Version | Evidence | PMID |
|---|---|---|---|---|---|
| MetaCyc | Entner-Doudoroff pathway III (semi-phosphorylative) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG (InterPro) | 00620 | Pyruvate metabolism | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
|
| MetaCyc | gluconeogenesis II (<i>Methanobacterium thermoautotrophicum</i>) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| MetaCyc | anaerobic energy metabolism (invertebrates, cytosol) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG | bps01200 | Carbon metabolism | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bps00230 | Purine metabolism | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bps00620 | Pyruvate metabolism | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| MetaCyc | Rubisco shunt | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG (InterPro) | 00230 | Purine metabolism | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
|
| KEGG | bps00010 | Glycolysis / Gluconeogenesis | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| MetaCyc | glycolysis II (from fructose 6-phosphate) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG | bps01110 | Biosynthesis of secondary metabolites | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| MetaCyc | 1-butanol autotrophic biosynthesis (engineered) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| MetaCyc | glycerol degradation to butanol | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG (InterPro) | 00010 | Glycolysis / Gluconeogenesis | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
|
| KEGG | bps01230 | Biosynthesis of amino acids | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| MetaCyc | photosynthetic 3-hydroxybutanoate biosynthesis (engineered) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| MetaCyc | glycolysis IV (plant cytosol) | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| KEGG | bps01100 | Metabolic pathways | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bps01130 | Biosynthesis of antibiotics | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | bps01120 | Microbial metabolism in diverse environments | 73.0+/03-31, Mar 15 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| MetaCyc | Entner-Doudoroff pathway I | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
||
| MetaCyc | superpathway of glucose and xylose degradation | InterPro 5.36-75.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| TIGRFAM | TIGR01064 | pyruv_kin: pyruvate kinase | IPR001697 | Pyruvate kinase | 3 | 474 | 7.0E-157 |
| PRINTS | PR01050 | Pyruvate kinase family signature | IPR001697 | Pyruvate kinase | 60 | 76 | 1.1E-56 |
| Pfam | PF00224 | Pyruvate kinase, barrel domain | IPR015793 | Pyruvate kinase, barrel | 3 | 340 | 2.9E-117 |
| PRINTS | PR01050 | Pyruvate kinase family signature | IPR001697 | Pyruvate kinase | 271 | 295 | 1.1E-56 |
| PRINTS | PR01050 | Pyruvate kinase family signature | IPR001697 | Pyruvate kinase | 296 | 314 | 1.1E-56 |
| PRINTS | PR01050 | Pyruvate kinase family signature | IPR001697 | Pyruvate kinase | 246 | 270 | 1.1E-56 |
| Gene3D | G3DSA:3.40.1380.20 | IPR036918 | Pyruvate kinase, C-terminal domain superfamily | 338 | 470 | 4.0E-163 | |
| PRINTS | PR01050 | Pyruvate kinase family signature | IPR001697 | Pyruvate kinase | 219 | 245 | 1.1E-56 |
| PRINTS | PR01050 | Pyruvate kinase family signature | IPR001697 | Pyruvate kinase | 185 | 199 | 1.1E-56 |
| SUPERFAMILY | SSF50800 | IPR011037 | Pyruvate kinase-like, insert domain superfamily | 71 | 164 | 1.05E-24 | |
| SUPERFAMILY | SSF51621 | IPR015813 | Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily | 2 | 340 | 9.77E-90 | |
| PRINTS | PR01050 | Pyruvate kinase family signature | IPR001697 | Pyruvate kinase | 315 | 331 | 1.1E-56 |
| Gene3D | G3DSA:2.40.33.10 | IPR015806 | Pyruvate kinase, insert domain superfamily | 71 | 167 | 4.0E-163 | |
| Gene3D | G3DSA:3.20.20.60 | IPR040442 | Pyruvate kinase-like domain superfamily | 3 | 337 | 4.0E-163 | |
| Pfam | PF02887 | Pyruvate kinase, alpha/beta domain | IPR015795 | Pyruvate kinase, C-terminal | 360 | 472 | 1.2E-30 |
| SUPERFAMILY | SSF52935 | IPR036918 | Pyruvate kinase, C-terminal domain superfamily | 349 | 475 | 1.83E-38 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.