Burkholderia pseudomallei K96243, BPSL0453

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL0453
Name
Replicon chromosome 1
Genomic location 491323 - 492900 (+ strand)

Cross-References

RefSeq YP_107078.1
GI 53718092
Entrez 3092266
GI 53718092
INSDC CAH34441.1
NCBI Locus Tag BPSL0453
RefSeq YP_107078.1,GeneID
UniParc UPI000043AC12
UniProtKB Acc Q63XT7
UniProtKB ID Q63XT7_BURPS
UniRef100 UniRef100_A0A069B462
UniRef50 UniRef50_Q2T1G5
UniRef90 UniRef90_Q2T1G5

Product

Feature Type CDS
Coding Frame 1
Product Name
cytochrome c oxidase
Synonyms
Evidence for Translation
Charge (pH 7) 2.71
Kyte-Doolittle Hydrophobicity Value -0.075
Molecular Weight (kDa) 55947.6
Isoelectric Point (pI) 7.62

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 444 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002693 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL0453

Human Homologs

Ensembl 97, assembly GRCh38.p12
mitochondrially encoded cytochrome c oxidase II [Source:HGNC Symbol;Acc:HGNC:7421]
E-value: 8.0e-33
Percent Identity: 35.7

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268