Burkholderia pseudomallei K96243, BPSL0385 (metH1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0046872 metal ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02310
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0031419 cobalamin binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02310
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0044237 cellular metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.20.20.20
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008705 methionine synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR02082
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009086 methionine biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR02082
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0042558 pteridine-containing compound metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS50972
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008270 zinc ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR02082
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Pathways

Database Xref Pathway Version Evidence PMID
MetaCyc folate transformations I InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG (InterPro) 00270 Cysteine and methionine metabolism InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bps00670 One carbon pool by folate 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG (InterPro) 00670 One carbon pool by folate InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bps01100 Metabolic pathways 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bps01230 Biosynthesis of amino acids 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG (InterPro) 00450 Selenocompound metabolism InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc L-methionine biosynthesis IV (archaea) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bps00450 Selenocompound metabolism 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bps00270 Cysteine and methionine metabolism 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bps01110 Biosynthesis of secondary metabolites 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc folate transformations II InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF52242 IPR036724 Cobalamin-binding domain superfamily 411 567 6.93E-43
ProSiteProfiles PS51332 B12-binding domain profile. IPR006158 Cobalamin (vitamin B12)-binding domain 415 554 42.452
SMART SM01018 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain 315 402 3.7E-43
ProSiteProfiles PS50974 AdoMet activation domain profile. IPR004223 Vitamin B12-dependent methionine synthase, activation domain 569 900 83.721
SUPERFAMILY SSF51717 IPR011005 Dihydropteroate synthase-like 17 291 1.23E-91
SUPERFAMILY SSF47644 IPR036594 Methionine synthase domain 310 401 3.53E-27
ProSiteProfiles PS50972 Pterin-binding domain profile. IPR000489 Pterin-binding domain 17 282 30.943
Coils Coil 553 573 -
Pfam PF02965 Vitamin B12 dependent methionine synthase, activation domain IPR004223 Vitamin B12-dependent methionine synthase, activation domain 610 885 4.4E-120
Gene3D G3DSA:3.40.50.280 412 568 2.4E-53
SUPERFAMILY SSF56507 IPR037010 Vitamin B12-dependent methionine synthase, activation domain superfamily 575 900 9.68E-120
PIRSF PIRSF000381 IPR011822 Cobalamin-dependent methionine synthase 1 873 0.0
Gene3D G3DSA:3.20.20.20 IPR011005 Dihydropteroate synthase-like 1 303 4.8E-132
Pfam PF02310 B12 binding domain IPR006158 Cobalamin (vitamin B12)-binding domain 417 510 1.9E-16
ProSiteProfiles PS51337 B12-binding N-terminal domain profile. IPR003759 Cobalamin (vitamin B12)-binding module, cap domain 308 406 37.674
Pfam PF02607 B12 binding domain IPR003759 Cobalamin (vitamin B12)-binding module, cap domain 317 394 2.8E-25
Gene3D G3DSA:1.10.288.10 609 771 3.0E-134
Pfam PF00809 Pterin binding enzyme IPR000489 Pterin-binding domain 21 259 4.7E-60
TIGRFAM TIGR02082 metH: methionine synthase IPR011822 Cobalamin-dependent methionine synthase 2 870 0.0
CDD cd02069 methionine_synthase_B12_BD IPR033706 Methionine synthase, B12-binding domain 317 544 2.84737E-131
CDD cd00740 MeTr 17 273 1.18078E-127
Gene3D G3DSA:3.10.196.10 IPR037010 Vitamin B12-dependent methionine synthase, activation domain superfamily 580 900 3.0E-134
Gene3D G3DSA:1.10.1240.10 IPR036594 Methionine synthase domain 307 399 1.9E-38

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.