Burkholderia pseudomallei K96243, BPSL0118

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0003916 DNA topoisomerase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00436
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003677 DNA binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00436
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003917 DNA topoisomerase type I activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00396
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006265 DNA topological change
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00436
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF01131 DNA topoisomerase IPR013497 DNA topoisomerase, type IA, central 154 595 2.9E-116
Pfam PF01751 Toprim domain IPR006171 TOPRIM domain 5 132 6.1E-12
CDD cd03362 TOPRIM_TopoIA_TopoIII IPR034144 DNA topoisomerase 3-like, TOPRIM domain 3 147 2.43043E-48
SUPERFAMILY SSF56712 IPR023405 DNA topoisomerase, type IA, core domain 3 609 3.4E-173
SMART SM00493 IPR006171 TOPRIM domain 3 126 9.9E-14
TIGRFAM TIGR01056 topB: DNA topoisomerase III IPR005738 DNA topoisomerase III 3 619 1.2E-168
CDD cd00186 TOP1Ac IPR013497 DNA topoisomerase, type IA, central 155 605 2.14101E-114
Pfam PF13342 C-terminal repeat of topoisomerase IPR025589 Topoisomerase C-terminal repeat 645 709 1.3E-19
SMART SM00436 IPR003601 DNA topoisomerase, type IA, domain 2 126 221 1.0E-23
PRINTS PR00417 Prokaryotic DNA topoisomerase I signature IPR013497 DNA topoisomerase, type IA, central 100 113 3.9E-27
MobiDBLite mobidb-lite consensus disorder prediction 841 855 -
SMART SM00437 IPR003602 DNA topoisomerase, type IA, DNA-binding domain 279 556 4.7E-74
PRINTS PR00417 Prokaryotic DNA topoisomerase I signature IPR013497 DNA topoisomerase, type IA, central 191 209 3.9E-27
Gene3D G3DSA:2.70.20.10 IPR013825 DNA topoisomerase, type IA, central region, subdomain 2 215 487 4.5E-160
Gene3D G3DSA:1.10.460.10 IPR013824 DNA topoisomerase, type IA, central region, subdomain 1 160 604 4.5E-160
ProSitePatterns PS00396 Prokaryotic DNA topoisomerase I active site. IPR023406 DNA topoisomerase, type IA, active site 316 331 -
Gene3D G3DSA:1.10.290.10 IPR013826 DNA topoisomerase, type IA, central region, subdomain 3 288 418 4.5E-160
MobiDBLite mobidb-lite consensus disorder prediction 813 869 -
Pfam PF13342 C-terminal repeat of topoisomerase IPR025589 Topoisomerase C-terminal repeat 756 816 9.1E-19
PRINTS PR00417 Prokaryotic DNA topoisomerase I signature IPR013497 DNA topoisomerase, type IA, central 519 533 3.9E-27
PRINTS PR00417 Prokaryotic DNA topoisomerase I signature IPR013497 DNA topoisomerase, type IA, central 404 420 3.9E-27
ProSiteProfiles PS50880 Toprim domain profile. IPR006171 TOPRIM domain 3 136 18.089
PRINTS PR00417 Prokaryotic DNA topoisomerase I signature IPR013497 DNA topoisomerase, type IA, central 322 331 3.9E-27
Gene3D G3DSA:3.40.50.140 3 153 3.0E-48

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.