Burkholderia cenocepacia K56-2, WQ49_RS04255 (paaK2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2
GCF_000981305.1|latest
Locus Tag
WQ49_RS04255
NCBI Old Locus TagWQ49_04260
Name
paaK2
Replicon scf7180000000049
Genomic location 366639 - 367961 (- strand)

Cross-References

RefSeq WP_006483970.1
GI 493529955
NCBI Locus Tag WQ49_RS04255
NCBI Old Locus Tag WQ49_04260
RefSeq WP_006483970.1

Product

Feature Type CDS
Coding Frame 1
Product Name
Paak2
Product Name Confidence: Class 1
Synonyms phenylacetate-CoA ligase
Evidence for Translation
Charge (pH 7) -4.43
Kyte-Doolittle Hydrophobicity Value -0.147
Molecular Weight (kDa) 48042.4
Isoelectric Point (pI) 6.30

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2Y4O LIGASE 01/07/11 Crystal Structure of PaaK2 in complex with phenylacetyl adenylate BURKHOLDERIA CENOCEPACIA 1.9 X-RAY DIFFRACTION 100.0

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003587 (315 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: WQ49_RS04255
Search term: paaK2
Search term: Paak2

Human Homologs

References

Defining a structural and kinetic rationale for paralogous copies of phenylacetate-CoA ligases from the cystic fibrosis pathogen Burkholderia cenocepacia J2315.
Law A, Boulanger MJ
J Biol Chem 2011 Apr 29;286(17):15577-85
PubMed ID: 21388965